Clonidine when added to intrathecal bupivacaine, prolongs the duration of analgesia.Our aim was to assess the effect of different dose of clonidine on duration of sensorymotor blockade and hemodynamic parameters. 120 patients of ASA grade I and II, aged 20-60 years scheduled for elective gynaecological surgeries were divided into four groups. Group ‘B’ being the control and received only 0.5% hyperbaric bupivacaine 15 mg. Group BC1, BC2, BC3 received injection clonidine 30; 45; 60 microgram respectively with 15 mg hyperbaric bupivacaine intrathecally. Patients were observed for duration of two segments regression of sensory block, recovery of motor block and duration of analgesia. Mean blood pressure, heart rate, oxygen saturation and sedation scores were monitored. The mean duration of sensory block was significantly longer in the group BC3 (232±13.49 min) as compared to BC2 (185±30.93 min) and BC1 (149±25.91 min) (p<0.001) respectively. While in B group it was (104±11.01 min). The mean duration of motor blockade was also found to be longer in group BC3 (334.0±22.06 min) as compared to BC2 (266±33.79 min) and BC1 (238±20.24 min) (p<0.0001) and in B group it was (165±22.39 min). Incidence of side effects was non-significant. Addition of clonidine to hyperbaric bupivacaine through intrathecal route increases the duration of sensorymotor blockade with postoperative analgesia in a dose dependent manner without increasing the side effects.
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